Journal article
18F-florbetaben Ab imaging in mild cognitive impairment
K Ong, VL Villemagne, A Bahar-Fuchs, F Lamb, G Chételat, P Raniga, RS Mulligan, O Salvado, B Putz, K Roth, CL Masters, CB Reininger, CC Rowe
Alzheimer S Research and Therapy | BMC | Published : 2013
DOI: 10.1186/alzrt158
Abstract
Introduction: 18F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Ab) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI). Methods: Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education. Results: High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in i..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was sponsored by Bayer Schering Pharma, Berlin, Germany, and funded in part by NHMRC grant 509166. Dr Kerryn Pike assisted with neuropsychology assessments. Ms Narelle Langdon, Mr David Baxendale, Dr Judith Adams and Ms Svetlana Pejoska assisted in participant screening and recruitment. Mr Gareth Jones organized and pre-processed the PET and MRI digital data.